Empire of Pain: The Book on the Opioid Crisis

By KaiRenner70
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The Most Important Journalism I Read Last Year

Patrick Radden Keefe spent years investigating the Sackler family and the role their pharmaceutical company played in creating the opioid crisis. Empire of Pain is the result: a multigenerational portrait of a family that understood what they were doing and chose to keep doing it. Keefe writes with precision and restraint that makes the subject more damning than outrage would. The book is important in the way that only well-reported and well-written nonfiction can be important.

NOW

Watching the Sackler naming controversies still unfolding

Updated Apr 2026
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Greed dressed as medicine causes a particular kind of harm that takes decades to name.

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Patrick Radden Keefe

journey·4 Sections

Reading Empire of Pain

Impact

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Section

Early Sackler chaptersOxyContin chaptersLegal sectionsFinal reckoning12345
Keefe does not spare the reader the damage done

This is the book I give to people who want to understand the opioid crisis as a human story rather than a policy problem. Both are true and this one starts with the humans.

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